The lab has been awarded a grant of 1.8 MSEK in total from The Swedish Cancer Society (swedish "Cancerfonden") to study matrix metalloproteinase triggered liposomal drug release for precision cancer therapy. The work will be conducted in collaboration with Prof. Torbjörn Bengtsson at Örebro University.
We have a new paper accepted in Biomedical Materials! Links will be provided to the paper as soon it is available for download.
M. Fürsatz, M. Skog, P. Sivlér, E. Palm, C. Aronsson, A. Skallberg, G. Greczynski, H. Khalaf, T. Bengtsson, D. Aili, "Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine", Biomedical Materials, 2017, Accepted.
Dr Robert Selegård, postdoc in the research group, has been accepted to give a oral presentation at the 2017 MRS Fall Meeting that will be held in Boston November 27th - December 1st. The title of the presentation is "Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan hybrid hydrogel" and will be presented at the "BM12—Biomolecular Self-Assembly for Materials Design" symposium.
Excerpt from the conference webpage: "Nature has evolved a variety of creative approaches to many aspects of materials design. One such approach is bio-molecular self-assembly, which represents a simple and efficient route to the construction of large, complex structures. This phenomenon is also a key process in all living organisms where many of the building blocks exhibit a hierarchy of structures that are critical to their functions. One area that is currently receiving significant attention is design of nanostructured and self-assembled materials exploiting the self-assembling properties of natural building block such as de-novo designed peptides and peptoids, oligonucleotides, protein, DNA and RNA molecules as well as their conjugates with synthetic polymer. Significant progress has been made towards understanding the design rules, mechanisms and driving forces behind the self-assembly of these systems. This has led to the design of a new generation of functional and responsive materials for a diverse range of applications, such as tissue engineering, drug delivery, biosensing, microelectronics, templating and energy harvesting.
This interdisciplinary symposium will bring together those working the field of materials design exploiting bio-inspired self-assembly of biological molecules including peptides and polypeptides, peptoids, oligonucleotides, protein, DNA and RNA as well as hybrid materials."
Dr Christopher Aronsson, postdoc in the research group, has been accepted to give a oral presentation at the Multiscale Mechanochemistry & Mechanobiology - From Molecular Mechanisms to Smart Materials conference that will be held in Berlin October 16th-18th. The title of the presentation is " Tailoring the rheological properties of supramolecular hydrogels for 3D cell culture by coiled coil polypeptide heterodimerization".
Excerpt from the conference website: "Mechanoresponsive materials are a topic of intense research across numerous disciplines. In biology, research on biogenic materials has revealed crucial links between specific protein building blocks and dynamic mechanical behaviors, while studies of biological tissues have identified sophisticated mechanotranduction mechanisms in cells for sensing their environment. Along similar lines, chemists and materials scientists are developing high-performance materials that exhibit specific programmed responses to mechanical stimuli (e.g. self-reporting and self-healing). Common to these diverse lines of research is a primary drive to understand dynamic responses of complex molecules to mechanical stimuli.
Motivated by this shared goal, this multidisciplinary conference will unite scientists from Biology, Chemistry, Physics and Materials Science, spanning multiple length scales and bridging gaps between experiment and simulation." – http://mechanochembio.mpikg.mpg.de/
Two new papers, one about hydrogels and one about antimicrobial peptides, have been accepted for publication! Links will be provided to each paper as soon they are availiable for download.
1) R. Selegård, C. Aronsson, C. Brommesson, S. Dånmark, D. Aili, "Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan hybrid hydrogel", Sci. Rep., 2017, Accepted.
2) T. Bengtsson, B. Zhang, R. Selegård, E. Wiman, D. Aili, H. Khalaf, "Dual Action of Bacteriocin PLNC8 αβ Through Inhibition of Porphyromonas Gingivalis Infection and Promotion of Cell Proliferation", Pathog. Dis., 2017, ftx064, Accepted article.
We are arranging a workshop to facilitate and stimulate collaboration between researchers at LiU and NTU (Singapore) in the field of materials science and nanotechnology. Please find the program here.