M2lab has together with several close collaborators received a framework grant from The Swedish Foundation for Strategic Research (SSF) for the project “HEALiX: Advanced Wound Care Materials for Non-Healing Wounds”. The projects will be led together with with Prof. Torbjörn Bengtsson (ÖrU), Dr. Johan Junker (LiU/KMC RÖ), and Kristiina Oksaman (LTU). Non-healing wounds leads to large suffering and are an enormous burden to the healthcare system. In a typical hospital setting, 25-40% of all beds are occupied by patients with wounds, and more than half of the health care resources in the outpatient setting are spent on wound treatment. HEALiX will bring together clinical and industrial wound care experts and leading academic researchers to address this huge medical and societal problem. Our aim is to develop a new generation of advanced but affordable multifunctional wound dressing materials that will give clinicians new and better means to go beyond wound management and instead focus on wound healing. We will jointly develop and evaluate advanced nanocellulose-based materials for moist wound healing and novel strategies to combine these materials with robust embedded diagnostic capabilities to facilitate treatment optimization. Moreover, strategies to combine nanocellulose wound dressing with peptide-based antimicrobial compounds will be explored to suppress infection and eradicate biofilms in non-healing wounds.
C. Skyttner, R. Selegård, J. Larsson, C. Aronsson, K. Enander, D. Aili, “Sequence and Length Optimization of Membrane Active Coiled Coils for Triggered Liposome Release”, BBA Biomembranes, 2018, In press, DOI: 10.1016/j.bbamem.2018.11.005 (PDF)
Rouhbakhsh, D. Aili, E. Martinsson, A. Svärd, M. Bäck, M. R. Housaindokht, K. P. R. Nilsson, R. Selegård, ” Self-Assembly of a Structurally Defined Chiro-Optical Peptide–Oligothiophene Hybrid Material”, ACS Omega, 2018, 3, 15066–15075.
The paper is available OA here!
The lab has been awarded a grant of 1.8 MSEK in total from The Swedish Cancer Society (swedish "Cancerfonden") to study matrix metalloproteinase triggered liposomal drug release for precision cancer therapy. The work will be conducted in collaboration with Prof. Torbjörn Bengtsson at Örebro University.
We have a new paper accepted in Biomedical Materials! Links will be provided to the paper as soon it is available for download.
M. Fürsatz, M. Skog, P. Sivlér, E. Palm, C. Aronsson, A. Skallberg, G. Greczynski, H. Khalaf, T. Bengtsson, D. Aili, "Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine", Biomedical Materials, 2017, Accepted.